[S2E7] Trial Error
When patients from the hospital's prescription drug trial start suffering life-threatening side effects, Nic fears that her sister Jessie may be in danger. As a result, she and Conrad work to convince Bell that these trials are not worth the risk. Meanwhile, Mina, Austin and Kit must set aside their competitive nature and work together on a patient whose health is quickly deteriorating and Devon uses Julian as the beta tester for a product he's designed.
[S2E7] Trial Error
Dr. Bell (Bruce Greenwood) ends up having to intervene in the medical brawl between hospital staff and the head of the clinical trial. Conrad and Nic attempt to have the trial shut down at the first sign of strange side effects, but the head of the clinical trial convinces Bell that they are normal. John and Jessie are the first patients to experience life-threatening side effects for a trial drug dealing with cancer. Bell immediately sides with Conrad and Nic to shut the trial down and to immediately place the remaining trial patients in the ICU for observation.
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The advent of more flexible clinical trial design brings a promise of greater hope in alleviating the challenges rare and orphan patients face in accessing clinical trials. However, just as creating a diagnosis and treatment plan is a slow and complex process, there is no simple path to innovation in clinical trials, and patient populations continue to struggle with availability, access, and exclusion/inclusion criteria.
Within the larger study of trial design, interest in nontraditional clinical trial models in the development and application of drug therapies is growing; two such examples are basket trials and umbrella trials. Basket trials are useful for diseases which have common molecular alternations. In a basket trial, a targeted therapy is evaluated on multiple diseases or disease subtypes. Umbrella trials evaluate multiple targeted therapies for a single disease that is stratified into subgroups by molecular alteration.
Pete stops the van after pulling off the road. He gets out of the van and yanks Dean out after him, throwing him to the ground. Pete tells Dean that the people in St. Louis will never buy Dean's story. "You're not going to make it to St. Louis," says Pete. "You're going to die, trying to escape". He pulls out his gun. "Wait, wait!" says Dean. "Let's talk about this. You don't want to do something you're going to regret. Well, maybe you do..." "Pete!", a voice interrupts. Both men turn to see Diana and Sam. Diana is pointing a gun at Pete. "Put the gun down," she says. "How did you find me?" he asks. "I know about Claire," says Diana. "I don't know what you're talking about," says Pete. " "Put the gun down!" says Diana again. "I don't think so," says Pete, still aiming the gun at Dean. "You're fast, but I'm faster". "Why'd you do it?" asks Diana. "I didn't do anything," replies Pete. "It's a little late for that," replies Diana. "It wasn't my fault," says Pete. "Claire was going to turn me in, I had no choice." "And Tony?" says Diana, "Karen?". "Same thing!" yells Pete. "Tony scrubbed the money, and then he got skittish, and he wanted to come clean. I'm sure he told Karen everything. It was a mess, I needed to clean it up. I panicked". "How many more people are going to die over this, Pete?" asks Diana. "There's a way out," says Pete. "This Dean kid's a friggin' gift. We could pin the whole thing on him, hey? No trial, nothing. Just one more dead scumbag". "Hey!" says Dean, and Pete aims the gun at him again. "No one will question it," he says. "Diana, I still love you." She slowly lowers the gun. "Thank you," says Pete. "Thank you." He turns toward Dean and suddenly Diana shoots him. Dean rolls out of the way. "Why don't you buy me another necklace, you ass," she says, and he suddenly jumps on her. Sam comes forward, but Pete aims the gun at him. "Don't do it! Don't do it!", Pete warns him. He aims the gun at Dean again. Both boys hold up their hands. Suddenly Diana looks behind Pete. Claire is standing there. Pete turns around and sees her, and then Diana shoots him from behind.
SERIES FINALE: Clary comes up with a plan that will bring Shadowhunters and Downworlders together, as Alec struggles for a way to help Magnus; Jonathan begins his reign of vengeful terror as the Shadowhunters try to find a way to stop him. With only one hope, Clary must make a sacrifice that could have long-lasting implications for all. Meanwhile, wedding bells are in the air for one special couple. 041b061a72